On the other hand, genes such as ST5, CTD small phosphatase-like gene, ras association domain-containing protein 1 tumor suppressors, which are down-regulated in invasive and metastatic malignancies, are the other targets of miR-99a, hence explaining the upregulation of miR-99a in MIBC and high grade tumors. The gene discussed is DENND2B; the disease is neoplasm.