PMNs are then directed to the infection site through GPCR recognition of a gradient of locally produced chemoattractants and inflammatory agents, including interleukin-8 (IL-8), platelet activating factor (PAF), leukotriene B4 (LT4), complement factor C5a, and the bacterial-peptide analog, fMLP, a neutrophil chemoattractant (Migeotte et al., 2006; Rabiet et al., 2007; Kolaczkowska and Kubes, 2013; Bloes et al., 2015; El-Benna et al., 2016). This evidence concerns the gene CXCL8 and infection.