In an older series of 52 PHEOs/PGLs patients (and n = 2 with VHL, one with nonmetastatic and one with metastatic disease), PET with 18F-DOPA and 18F-FDA had showed the same lesions; both were better than 123I-MIBG in imaging the patient with metastatic disease (34). This evidence concerns the gene VHL and metastatic neoplasm.