In fact, S1P induced-migration via S1P1 and S1P3 receptors was demonstrated in activated HSCs (Brunati et al., 2008), human HSCs line LX-2 (Liu et al., 2011), bone marrow-derived monocyte/macrophage (BMMs) migration in mouse models of cholestatic liver injury (Li et al., 2009a,b; Yang et al., 2013, 2015), human hepatic myofibroblasts (hMFs) (Li et al., 2011), and CCl4-induced liver fibrosis (Ikeda et al., 2009; González-Fernández et al., 2017). Here, S1PR1 is linked to Hepatic fibrosis.