TGFB1 and Hepatic fibrosis: The immune response, that has multiple interactions with the fibrogenic process, may be also a candidate for therapy (Pellicoro et al., 2014); thus, several strategies to block the TGF-β activity have shown efficacy (Vogt et al., 2011; Rogler et al., 2017), and inhibition of chemokines and their receptors demonstrated antifibrotic effects in rodent models of liver fibrosis (Zaldivar et al., 2010; Seifert et al., 2015; Zubiete-Franco et al., 2017).