ACHE and Alzheimer disease: Based on these pathogenesis, there are more than 200 enzymes or proteins related to AD, such as AchE, BACE1, GSK3β, MAO-B, GABA-A receptor, Glutamate receptor, and so on (Saura et al., 1994; Sathya et al., 2012; Fang et al., 2015; Yan et al., 2016).