In this regard, there are in literature data on impaired insulin action or production, impaired signaling pathway involving insulin receptor (IR) and insulin growth factor (IGF) defects, toxicity caused by hyperglycemia, increase of advance glycation end products, inflammation at the vascular level and others (Sjöholm and Nyström, 2006; Luchsinger, 2012; de la Monte, 2012). Here, INSR is linked to Hyperglycemia.