AMFR and melanoma: As described earlier, the monoclonal antibody 3F3A, directed against AMFR/Gp78 in B16-F1 melanoma cells, possibly binds to AMFR in a manner similar to AMF and thus mounting similar effects, including increased cell motility leading to the identification of Gp78 as the receptor protein for AMF (Nabi et al., 1990, 1992).