A reciprocal relationship between expressions of E-cadherin, a cell adhesion protein and Gp78 has been observed in tissues from bladder carcinomas (Otto et al., 1994), which was later confirmed in another study, where MSV transformed MDCK cell population has been found with lowered E-cadherin and upregulated Gp78 protein expression levels (Simard and Nabi, 1996). The gene discussed is CDH1; the disease is urinary bladder carcinoma.