AMFR and cancer: Despite several studies indicating the correlation between Gp78 with metastasis in various cancers, the mechanism of how AMFR aids in metastasis was revealed later with identification of Gp78 mediated degradation of metastasis suppressor protein Kangai1 (KAI1), which results in induction of metastasis potential of different cancer cell lines, as well as Gp78-overexpressing transgenic mice (Tsai et al., 2007; Joshi et al., 2010).