Esophageal squamous cell carcinoma patients were examined for Gp78 expression and its association with different tumor characteristics; such as, size, growth, invasion and metastasis and again it was found that patients with higher expression of Gp78 have increased risk of cancer with lower survival rate (Maruyama et al., 1995). The gene discussed is AMFR; the disease is esophageal squamous cell carcinoma.