In tongue squamous cell carcinoma and hepatocellular carcinoma (HCC) patients, higher expressions of AMFR, along with Ras homolog family member C (RhoC) and c-met coincides with increased risk of invasion and disease recurrence with low survival (Endo et al., 2006; Wang et al., 2007). The gene discussed is RHOC; the disease is tongue squamous cell carcinoma.