Liver-specific Gp78 knockout mice have decreased HMGCoR and Insig-1 degradation, which may also cause suppressed levels of sterol-regulatory element binding protein (SREBP), leading to an overall decrease in lipid biosynthesis of the cell, which could be advantageous to patients suffering from metabolic disorders (Liu et al., 2012). The gene discussed is AMFR; the disease is metabolic disease.