Functional association of AMFR in cell signaling (Luo et al., 2002), metabolism (Watanabe et al., 1996), cell motility (Liotta et al., 1986); and regulatory control over cancer cell metastasis (Nabi et al., 1992), mitophagy (Fu et al., 2013) and ERAD are some major tasks, which this glycoprotein has been attributed so far. Here, AMFR is linked to cancer.