The role of MTHFR C677T (rs1801133; A222V) polymorphism encoding the thermolabile MTHFR in cardiovascular disease is controversial and there is conflicting opinions on its role in thrombosis pathogenesis [7], but it is nevertheless associated with hyperhomocysteinemia, a condition that causes multiple disorders [8]. The gene discussed is MTHFR; the disease is hyperhomocysteinemia.