SH2D1A and parasitic infectious disease: Interestingly, both P. chabaudi-specific B-cell responses and the course of P. chabaudi infection in ICOS-deficient mice resemble our observations in SAP-deficient mice more closely than in Bcl6fl/flCD4-cre+/− mice (i.e. partial, but not complete, abrogation of the GC B cell response and P. chabaudi-specific IgG responses, and highly variable control of the parasitemia late during chronic infection) (Wikenheiser et al., 2016).