Generally, an IGF-I > 1.2 × upper limit of normal or the worst tumor status (both indicated as level 3) tended to have high scores for S-DA and very low scores for S. Similar patterns for the highest levels of severity were observed for comorbidities, symptoms, and HRQoL impairment; however, the distributions were less extreme. The gene discussed is IGF1; the disease is neoplasm.