HNF4A and colorectal carcinoma: After nuclear translocation, β-catenin interacts with TCF/LEF transcription factors and induces the expression of genes responsible for the regulation of cell cycle (CCND1, c-MYC), cell migration (MMP-7), and apoptosis (BIRC5) and of other regulators including Axin2. Around half of CRC patients bear inactivating mutations in the APC gene.