More intriguingly, comparison of the modified CRC cell line SW620/shMIER3 and its control group showed that silencing endogenous MIER3 induced non-invasive epithelial cells to acquire a mesenchymal, spindle cell phenotype, suggestive of epithelial-mesenchymal transition (EMT) (Fig. 5B). This evidence concerns the gene MIER3 and colorectal carcinoma.