TP53 and central nervous system cancer: KEGG pathways show an impressive functional association with various signal-related and cancer-related pathways, such as Signaling pathways regulating pluripotency of stem cells (P = 6.78 × 10−5), p53 signaling pathway (P = 1.07 × 10−4), and PI3K-Akt signaling pathway (P = 1.02 × 10−4), Prostate cancer (2.67 × 10−7), Glioma (5.22 × 10−7), Proteoglycans in cancer (2.09 × 10−5), Pathways in cancer (6.62 × 10−5), Non-small cell lung cancer (8.70 × 10−5) (Fig. 3B).