PSD-95 also links the kainate receptor (GRIK2) with c-Jun-N-terminal kinase (JNK) activation9, and a peptide designed against the C-terminus of GRIK2, Tat-GluR6-9c, showed a protective effect against neuronal death induced by cerebral ischemia/reperfusion10. This evidence concerns the gene GRIK2 and Cerebral ischemia.