To date, biologics such as tumor necrosis factor alpha (TNFα) blockers3 have been used as RA therapy, as have non-steroidal anti-inflammatory drugs (NSAIDs), steroids, and disease-modifying anti-rheumatic drugs (DMARDs) such as methotrexate followed by TNFα inhibitors4. The gene discussed is TNF; the disease is rheumatoid arthritis.