Incubation of tendon-derived stromal cells from both healthy volunteers and patients with tendinopathy in SPM including 15-epi-LXA4 or MaR1 induced further release of proresolving mediators and counter regulated the expression of pro-inflammatory molecules including PGE2, IL-6, STAT-1 and PDPN. The gene discussed is STAT1; the disease is disease of the tendon.