ACE and metabolic syndrome: In metabolic syndrome, a dysregulation of nitric oxide signaling may interfere with efficacy of some conventional drugs used; on the other hand, certain medications such as statins, angiotensin‐converting enzyme inhibitors, angiotensin receptor blockers, or β blockers may exert their therapeutic effects via modulation of nitric oxide signaling.52 Under such circumstances traditional medications may weaken the effect of nitrate supplementation.