The results showed that hepatic MDA levels not only in Tau + wsTP treated NASH rats but also in Tau + lsTP treated NASH rats, decreased significantly compared with those in NASH rats (P < 0.01), and hepatic SOD activity increased significantly (P < 0.01) in both groups compared with that in NASH rats. Here, SOD1 is linked to metabolic dysfunction-associated steatohepatitis.