When taurine and lsTP were both given to NASH rats, results showed that serum ALT, AST, TC, TG and LDL-C levels all decreased significantly (P < 0.01), moreover, the downtrend in AST and TC in the Tau + lsTP treatment group was more significant than that in the taurine treatment group or the lsTP treatment group (P < 0.05 or P < 0.01), the downtrend in ALT in the Tau + lsTP group was more significant than that in the lsTP treatment group (P < 0.01), and the downtrend in TG in the Tau + lsTP group was more significant than that in the taurine treatment group (P < 0.01). The gene discussed is GPT; the disease is metabolic dysfunction-associated steatohepatitis.