ANXA2 and cancer: High level of Annexin A2 was detected in various malignant tumors, including brain tumors [7], colorectal cancer [8], gastric cancer [9], pancreatic cancer [10], breast cancer [11], hepatocellular cancer [12], and lung cancer [13], and this abnormal expression of Annexin A2 was positively correlated with the differentiation status, histological type, lymph node metastasis and distant metastasis, as well as poor prognosis [14, 15].