More important, knockdown of Annexin A2 significantly increased the drug-sensitization of cisplatin in vivo, in that the tumor volume in A549/DDP/Annexin A2 shRNA-bearing mice treatment with cisplatin was significantly less than that in A549/DDP/Control shRNA-bearing mice (337.4 ± 108.5 mm3 vs. 799.6 ± 104.8 mm3) (Fig. 2b). The gene discussed is ANXA2; the disease is neoplasm.