PLEK and asthma: The positive regulation of blood coagulation (GO:0030194) gene set was overrepresented and included S100A9, PLEK, THBS1 and TLR4. Chronic up-regulation of coagulation [81] and systemic inflammation were reported in horses with severe asthma [82], and activation of the coagulation cascade [81] together with impaired epithelial repair [83] are features of human asthma.