All genes associated with 4 or more gene sets have also been associated with asthma in humans or mice and include S100A9, thrombospondin 1 (THBS1), TLR4, IL8, complement component 5a receptor 1 (C5AR1), MMP9, NLR Family, Pyrin Domain Containing 12 (NLRP12) and triggering receptor expressed on myeloid cells 1 (TREM1) [20, 38–48]. Here, TLR4 is linked to asthma.