White pitaya juice and purified peel betacyanins (PPBNs) improved insulin resistance through decreasing fibroblast growth factor-21 (FGF-21) expression and increasing level of FGF-21 related genes (Klb, FGFR2, Egr1 and cFos) in the liver [9, 27]. This evidence concerns the gene FGFR2 and Insulin resistance.