CASQ2 overexpressing transgenic mice develop dilated cardiomyopathy with reduced SERCA2a expression and increased expression of cardiac remodeling-related proteins such cardiac ankyrin repeat protein (CARP), glutathione peroxidase, decorine (Dcn), TGF-b1-stimulated clone-36 protein (TSC-36), microfibril-associated glycoprotein-2 (Magp2) and osteoblast-specific factor-2 (Osf2) [37]. Here, ANKRD1 is linked to dilated cardiomyopathy.