The degradation of H2O2 by cell-permeable PEG-catalase and/or neutralization or sequestration of aminoaldehydes by N-2-MPG or PLZ, respectively, reduced the severity of cisplatin AKI, as determined by reductions in serum creatinine levels and the extent of renal tubular damage (Fig 5). The gene discussed is CAT; the disease is acute kidney injury.