CAT and acute kidney injury: In order to ascertain the role of these molecules in the mediation of cisplatin AKI, the effect of treatment with reagents that degrade H2O2 (e.g. cell permeable polyethyleneglycol conjugated catalase; PEG-Cat) and compounds that neutralize (e.g. N-2-mercaptopropionyl glycine, N-2-MPG) or sequester (e.g. phenelzine; PLZ) aminoaldehydes and acrolein on the severity of renal dysfunction and tubular damage caused by cisplatin was determined.