GMNN and neoplasm: Finally, a multivariable analysis determined that large tumor size (OR: 6.438, 95% CI: 2.224–20.946, p = 0.0005) and high levels of geminin (OR: 6.497, 95% CI: 2.427–19.202, p = 0.0001) were independent and significant predictive factors (Table 2).