ESR1 and cancer: As shown in Table 1, SUVmax-high cancers were significantly more frequent in cancers with a large tumor size (>2cm, p<0.0001), nuclear grade 3 (p<0.0001), ER-negative (p = 0.0010), PgR-negative (p = 0.0013) and high Ki67 expression levels (p<0.0001).