However, several nonsynonymous SNPs in IL17REL have been demonstrated to be associated with ulcerative colitis (p.Leu333Pro, rs5771069; p.Pro262Leu, rs142430606; p.Glu151Gly, rs200958270) [47,48] and atrial fibrillation (p.Glu151Gly, rs200958270), the latter of which is the most common cardiac arrhythmia in males [49–51]. The gene discussed is IL17REL; the disease is cardiac rhythm disease.