Both DU145 and PC3 cell lines express ROR-2 [46] and it is known that the WNT5A associated Frizzled receptors Fzd-2, Fzd-3, Fzd-5 and Fzd-7 are also expressed on these cells as well as on other PCa cell lines [46,52–54]. Here, FZD3 is linked to posterior cortical atrophy.