This hypothesis was tested using cytokine profiling of mouse brain tissue and human neural cell cultures that were exposed to oxidative stress or pro-inflammatory stimuli after knockdown or over-expression of SLC1A1. Finally, to examine the impact of SLC1A1 haploinsufficiency on global brain function, we used RNA-Seq to determine whether this loss of function produces transcriptional effects on other schizophrenia-related, neuroimmune-related, and synaptic-related genes in the mouse brain tissue. The gene discussed is SLC1A1; the disease is schizophrenia.