Given the significance of oxidative stress in the pathophysiology of schizophrenia and the important role of EAAT3 in neuronal GSH synthesis, we tested whether Slc1a1 haploinsufficiency could affect the redox state of glutathione (GSH/GSSG ratio) in the brain, as an indicator of cellular oxidative stress. This evidence concerns the gene SLC1A1 and schizophrenia.