CD4 and AIDS: For instance, Fig 3 shows the estimated by-year probabilities for the 3 transition rates corresponding to a “high-risk patient”: male, aged >50 years, CD4<500 cell/mL and RNA HIV >100.000 c/mL at engagement, non-sexual transmission, previous AIDS events, cohort inclusion before 2008, hepatitis C virus coinfection, CD4 cell at NAE development <500 cell/mm3 and RNA HIV at NAE above the limit of detection.