TLR9 and cancer: This TLR9 variant has been previously associated with a decreased breast cancer risk.[25] Specifically, the T allele was suggested to be protective of breast cancer in a recent meta-analysis consisting of 12,197 cancer cases and 13,488 controls.[25] We identified a significantly higher T allele frequency in EAs compared to AAs (55.17 vs. 34.52, p = 2.20E-16), suggesting EAs benefit more from the T allele’s protective effects than AAs.