Our finding that septic neonates had significant reduction of the proportion of genes representing TLR, TREM-1, and iNOS signaling pathways as compared to septic infants, children, and adults, in concert with the reduced expression of multiple cytokine receptors, are consistent with several studies that have demonstrated a reduced early inflammatory response to pro-inflammatory triggers or sepsis in neonates as compared to infants, children, and adults [10–13, 24]. The gene discussed is NOS2; the disease is Sepsis.