Polypoidal choroidal vasculopathy (PCV) is a common retinal disease in Asians, characterized by abnormal vascular channels and polypoidal vascular dilatation which could be observed on indocyanine green angiography (ICGA).[1,2] Although about half of patients with PCV will have a favorable natural course, the remaining half lose their vision due to recurrent bleeding and persistent exudation.[3] Unfortunately, anti-vascular endothelial growth factor (VEGF) treatment is less useful for patients with PCV than in those with typical age-related macular degeneration (AMD). The gene discussed is VEGFA; the disease is Polypoidal choroidal vasculopathy.