Beyond these cell cycle proliferation markers, elevated expression of genes associated with anti-apoptosis or cell cycle progression (PCNA, CDC25B and BIRC3), angiogenesis (ELF4, PLCG2, SHC1, POSTN and DOK2) and downregulation of anti-angiogenic signalling (ANGPTL1), together relays another tier of accelerated cell growth signatures in these tumours (Table D in S2 File). Here, PCNA is linked to neoplasm.