Similar findings for most parameters were present in patients with T2DM, serum T, FT, E2, FE2 (all P<0.001), DHT (P = 0.003), SHBG (P = 0.007), LH (P = 0.001) and FSH (P = 0.008) levels during CC treatment being significantly increased, whereas in the Plac treatment group no significant change occurred in any of the parameters, except for an increase in FT (P = 0.005) and FSH (P = 0.002) levels. Here, PLOD1 is linked to type 2 diabetes mellitus.