During the CC treatment serum T (P<0.001), FT (P<0.001), DHT (P<0.001), E2 (P<0.001), FE2 (P<0.001), SHBG (P = 0.001) and both gonadotropins (LH: P<0.001 and FSH: P<0.001) increased significantly from baseline in the overall population, regardless of their metabolic condition (IGT or T2DM). Here, PLOD1 is linked to type 2 diabetes mellitus.