As far as the metabolic profile is concerned, the change of glucose fasting levels after Plac treatment became significant both in all subjects and in T2DM patients (sensitivity analysis: P = 0.039 and P = 0.021, respectively; entire population: P = 0.133 and P = 0.090, respectively), whereas the change of insulin fasting levels observed after CC treatment in all subjects failed to reach the significant level (sensitivity analysis: P = 0.116; entire population: P = 0.010). Here, INS is linked to type 2 diabetes mellitus.