B cell phenotype analysis has shown that no significant differences were detected in BAFF-R (both frequency and MFI) and BCMA expression after biologic therapy irrespective of response to treatment, but TACI expression significantly increased in RA patients after biologic therapy who had a low to moderate, but not high, disease activity after treatment (Fig 12). The gene discussed is TNFRSF13B; the disease is rheumatoid arthritis.