More tubulointerstitial fibrosis was found in Trichrome-stained kidney sections (Fig 3A), quantitative analysis of Sirius red stain (Fig 3B), and SMA expression was higher (Fig 3C) at Day 7 post-IRI in PLC3 mice than LC3 mice, suggesting that CRP mice are more susceptible to develop renal fibrosis after ischemic injury. This evidence concerns the gene SMN1 and renal fibrosis.