Emerging evidence showed that CRP is not only a biomarker, but also a contributor to AKI, because CRP was reported to promote AKI by enhancing inflammation, shifting the balance of macrophage activation and FcγR expression towards a detrimental portfolio[41], or impairing G1/S-dependent tubular epithelial cell regeneration [11]. The gene discussed is FCGR2A; the disease is acute kidney injury.