In particular, mouse mutants lacking adiponectin, the ligand for AdipoR1 and AdipoR2, develop metabolic complications (glucose intolerance, insulin resistance) only when fed a high fat diet [40], which is analogous to the C. elegans paqr-2 mutants that show severe phenotypes when fed a SFA-rich diet. This evidence concerns the gene ADIPOR1 and Insulin resistance.