The assignment of these proteins to a common pathway is further supported by the observation that human mutations in WNT5A, ROR2, DVL1 and DVL3 can cause Robinow syndrome, a congenital disorder characterized by short-limbed dwarfism and morphological defects in craniofacial and genital structures, demonstrating that the Wnt5a-Ror-Dvl pathway regulates morphogenesis during human development (Afzal et al., 2000; van Bokhoven et al., 2000; Person et al., 2010; Bunn et al., 2015; White et al., 2015, 2016). Here, WNT5A is linked to Robinow syndrome.