Thus, many genes involved in PPAR‐targeted functions were regulated, including lipid metabolism (CIDEA, SCD, and Fabp3), chronic kidney disease (FGF23), ion transport (Atp2a1 and Atp1a2), mitochondrial oxidative phosphorylation (Cox8b), stress response (Gpx3), inflammation (IL‐10 and IL‐1β), immunity (TLR2‐9 and NODR1‐2), and water channel (AQP3‐5). Here, COX8BP is linked to chronic kidney disease.