TNFRSF8 and neoplasm: This raises the question of whether the activation of different regions is cell-type or ligand specific, and therefore whether this differential effect can be harnessed clinically.45 Indeed, one of the difficulties in understanding the pleiotropic effects of CD30 stimulation extends from the fact that these studies were performed in variable cognates in tumor cell lines, without a concomitant clear explication of the effects of CD30 stimulation by CD30L in normal tissues.