Certainly the finding that the NFkB and mitogen-activated protein kinase/extracellular signal-regulated kinase pathways are integral to CD30-mediated signaling suggests that CD30 expression may confer a proliferative and anti-apoptotic benefit in neoplastic cells.44, 45, 46 Horie et al. proposed a link between CD30 overexpression and ligand-independent stimulation of the NFkB pathways in HL cells, underscoring a possible link between CD30 expression and tumor perpetuation. This evidence concerns the gene TNFRSF8 and neoplasm.