TNFRSF8 and anaplastic large cell lymphoma: While CD30 downregulation is a putative mechanism, and was seen in vitro, this finding was not seen in the tissue samples examined in this study,97 mirroring prior case reports of persistent CD30 expression even in the setting of reduced BV efficacy.98 However, cases of relapsed/refractory ALCL with downregulation of CD30 following BV treatment have also been reported.99, 100, 101