TNFRSF8 and neoplasm: The BerH2 antibody is used for routine assessment of CD30 expression in tissue specimens, with good correlation between immunohistochemical protein expression and specific mRNA levels.25, 26 Kim et al. reported the use of multi-spectral imaging in their study of brentuximab vedotin (BV) in CTCL, quantifying CD30 expression in biopsies otherwise designated CD30-negative by immunohistochemistry (IHC), thus defining a ‘low-level positive’ tumor group.