Initial preclinical studies in the mid- to late 1990s used murine anti-CD30 mAbs, with reported improved disease-free survival rates in xenograft mice treated with M44 or HeFi-1, and, in a later study using HeFi-1, tumor growth arrest or regression in an ALCL xenograft model.58, 59 Leading on from these studies, focus was directed to the creation of humanized mAbs, resulting in the development of SGN-30, a chimeric mouse-human antibody, and the fully humanized mAb 5F11 (MDX-060, or iratumumab). Here, TNFRSF8 is linked to neoplasm.