Ex vivo studies using blood samples obtained from patients suffering different diseases, namely Parkinson, essential hypertension, glaucoma, retinal vasculitis, amyotrophic lateral sclerosis (ALS), and Hirschsprung’s disease, have evidenced augmented levels of RBC AChE enzyme activity [44,45,46,47,48,49]. This evidence concerns the gene ACHE and amyotrophic lateral sclerosis.