CD8A and neoplasm: Analyzing these correlations across topological groups, we further observed: (1) a significant positive correlation between CD3+ and CD8+ TILs at the tumor center (r = 0.496, p = 0.031); (2) a significant positive correlation between FoxP3+ TILs at the tumor center and Ki67+ TILs both at the tumor center (r = 0.803, p = 0.000) and margin (r = 0.457, p = 0.043); (3) a significant positive correlation between C3FR and C8FR at the invasive edge (r = 0.884, p = 0.000).