These findings might be indicative of the presence of two different protective networks against relapse: a protective “effector” TIL network (CD3–CD8) at the tumor center, as well as a protective “effector/suppressor” TIL balance (C3FR–C8FR) at the tumor margin, possibly relevant to keep relapse-initiating CSCs and EMT dormant. Here, CD8A is linked to neoplasm.