MAPK3 and neoplasm: From a biochemical point of view, both cathechins and rutin given at different doses (0.02%, 0.04%, 0.08%, 0.16%, or 0.32%) for 6 weeks as the sole source of drinking fluid to tumor-bearing mice increased the levels of E-cadherin on the plasma membrane, and decreased those of nuclear β-catenin, c-Myc, phospho-AKT, and phospho-ERK1/2 in the tumors [33].