In isolated neutrophils, Dewas et al. [85] reported that sepsis-induced pro-inflammatory cytokines (TNF-α, IL-1 and G-CSF) activated the assembly of reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase on the outer cell membrane and triggered the subsequent “respiratory burst” [86], generating powerful reactive oxygen species (ROS) that are used to destroy engulfed bacteria. Here, FMO5 is linked to Sepsis.