Besides, in consideration of the gene chip with high throughput that could determine the different functional status and core gene expressions at the same time, we used the Affymetrix Mouse Gene 2.1 ST Array Strip (Thermo Fisher Scientific, Waltham, MA, USA) gene chip to screen significantly different genes and discovered gene expression profiles between the HFD group and the MDG-1 prevention group, thus exploring more deeply the mechanism of MDG-1 on hyperlipidemia. This evidence concerns the gene DNAJB9 and hyperlipidemia.