DNAJB9 and obesity due to melanocortin 4 receptor deficiency: We found that after 12 weeks of prevention trials, the MDG-1 intervention group was clustered together, and was relatively distant from the HFD group but close to the normal group based on the results of 3D-PCA, suggesting a trend towards recovery when using MDG-1 against HFD-induced obesity in experimental mice (Figure 5a).