Prior reports have shown that intraocular pressure may be associated with cardiovascular risk factors.[13,14] Metabolic syndrome (MetS) is a cluster of cardiovascular risks, and high intraocular pressure is observed in subjects with MetS.[14–16] C-reactive protein (CRP), a novel biomarker for systemic inflammation, has been shown to be a predictor of a cardiovascular disease in subjects with and without MetS.[17] We hypothesized that chronic inflammation, reflected by serum CRP levels, has a synergistic effect on elevating intraocular pressure in subjects with MetS. Here, CRP is linked to metabolic syndrome.