ADAMTS13 and thrombotic thrombocytopenic purpura: Analysis of five accessible reports showed a median interval of 2 weeks (4 days to 3 months) between immunization and onset of HUS (n = 2) and (presumed) TTP (associated with depleted ADAMTS13 activity and/or increased anti-ADAMTS13 antibodies; n = 3) [43, 72–75].