Taking into account the characteristics of our population (Tables 1, 3), we conducted stepwise logistic regression analysis using as covariates age, sepsis, shock, previous hepatopathy, secondary ARDS, SAPS II, SOFA at admission and the worst value [TIMP-2]·[IGFBP7] for AKI and AKIN ≥ 2 prediction. The gene discussed is TIMP2; the disease is Sepsis.