Previous studies in unselected ICU populations have shown that when analysed together as the index [TIMP-2]·[IGFBP7], they perform better than sCr, urine and plasma NGAL, plasma cystatin-C and KIM-1 for early detection of AKI and improved risk stratification for renal and general outcomes [15, 16]. This evidence concerns the gene TIMP2 and acute kidney injury.