The AUROC curve of the worst value [TIMP-2]·[IGFBP7] within the first 12 h of ICU admission for AKI prediction was 0.798 (0.709–0.886, p < 0.0001)) for an index value of 0.40, with sensitivity of 73.5% (95% CI 69.7–77.5%) and specificity of 71.4% (95% CI 67.4–75.4%) (Table 4; Fig. 3). The gene discussed is IGFBP7; the disease is acute kidney injury.