In the present study, we explored possible association between KCNQ5 polymorphisms and high myopia for five SNPs (rs9342979, rs9351953, rs3920868, rs7775087, and rs7744813) that were common variants in a hotspot region of KCNQ5 gene, with an MAF > 0.10, and in LD with rs7744813 previously found to be associated with refractive error and myopia. The gene discussed is KCNQ5; the disease is refractive error.