Cytoplasmic localization of Pontin was also reported in human colorectal cancer (CRC) and lymphoma tissue sections, as well as in PDAC cells, embryonic stem cells (ESCs), and HeLa cells; while Reptin cytoplasmic localization was found in HEK293 cells, HeLa cells and adipocytes (Makino et al., 1998; Mizuno et al., 2006; Lauscher et al., 2007; Ni et al., 2009; Xie et al., 2009; Taniuchi et al., 2014; Baron et al., 2016). This evidence concerns the gene RUVBL2 and colorectal cancer.