A similar phenotype was observed upon Pontin/Reptin silencing in many other cancer models such as prostate cancer (LNCap), HCC (HuH7, Hep3B), PDAC (S2-013), and hypoxia treated breast cancer cells (MCF7) (Kim et al., 2006; Rousseau et al., 2007; Lee et al., 2010; Taniuchi et al., 2014). This evidence concerns the gene RUVBL2 and hepatocellular carcinoma.