Several studies have reported Pontin and/or Reptin expression in both non-small cell lung cancer (NLSCLC) and small cell lung cancer (SCLC) and suggested their potential use as biomarkers for diagnosis and prognosis of lung cancer (Dehan et al., 2007; Ocak et al., 2014; Uribarri et al., 2014; Yuan et al., 2016; Velmurugan et al., 2017) (Table 1). The gene discussed is RUVBL2; the disease is small cell lung carcinoma.