Studies in a variety of cancer cell lines have consistently demonstrated that downregulation of either Pontin or Reptin may lead to cell cycle arrest at the G1/S phase checkpoint, resulting in the accumulation of cells in G1 and a reduction of cells in all other phases of the cell cycle (S, G2/M) (Rousseau et al., 2007; Haurie et al., 2009; Menard et al., 2010; Osaki et al., 2013; Ren et al., 2013; Breig et al., 2014; Zhang et al., 2015; Yuan et al., 2016). Here, RUVBL2 is linked to cancer.