Nuclear β-catenin expression significantly decreased following Pontin depletion in RCC, supporting a hypothesis that during oncogenesis, Pontin may upregulate β-catenin transcription targets by relocating β-catenin from the adherens junctions to the nucleus, thus increasing transcription of oncogenes such as MYC (Ren et al., 2013). The gene discussed is RUVBL1; the disease is renal cell carcinoma.