Through ChIP-seq studies, the authors also showed that the chromatin remodeling effects of Pontin and Reptin were not through the TIP60 histone acetyltransferase (HAT) complex that Pontin and Reptin are subunits of (as described above), since TIP60 was not observed at the promoters of E2F1 target genes in this model of HCC. The gene discussed is E2F1; the disease is hepatocellular carcinoma.