Within the digestive system (Table 1), Pontin and/or Reptin were implicated in cancers of the esophagus, stomach, colon, and pancreas (Li et al., 2010; Lauscher et al., 2012; Tung et al., 2013; Taniuchi et al., 2014; Cui et al., 2016). This evidence concerns the gene RUVBL1 and cancer.