TP53 and cancer: Reptin was found to interact with wild-type p53 and suppress its anti-tumor activity (Table 2) through an interaction with anterior gradient-2 (AGR2) protein, a potent inhibitor of p53-mediated transcription that promotes cancer cell proliferation, survival, and metastasis (Figure 5E) (Maslon et al., 2010; Gray et al., 2013; Ocak et al., 2014; Clarke et al., 2016).