In addition, Pontin and Reptin were critical regulators of AML1-ETO (in acute myeloid leukemia) and MLL-AF9 (in mixed lineage leukemia), respectively, where their ATPase activities were required for clonogenesis and survival of the cancer cells (Osaki et al., 2013; Breig et al., 2014). Here, RUVBL1 is linked to cancer.