AGT and hypertensive disorder: Previously, researchers have also propounded that Ang II-induced hypertension can take place through cellular events including promotion of phospholipase C and phosphatidylinositol hydrolysis, enhancement of intracellular free calcium concentration, activation of protein kinase C and decreased release of NO (Carey and Siragy 2003 ▶; Touyz 2003 ▶; Touyz and Schiffrin, 2000 ▶).